Optimization of pyrrolidinone based HIV protease inhibitors

Bioorg Med Chem Lett. 2005 Jan 3;15(1):81-4. doi: 10.1016/j.bmcl.2004.10.029.

Abstract

Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very potent antiviral activity.

MeSH terms

  • HIV Protease Inhibitors / chemistry
  • HIV Protease Inhibitors / pharmacology*
  • Models, Molecular
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / pharmacology*

Substances

  • HIV Protease Inhibitors
  • Pyrrolidinones